CNS effects may persist after peripheral features have resolved.More severe cases may present with seizure and/or coma.Most often causes agitated delirium (often with hallucinations, incoherent speech, picking at the air or objects).Mad as a hatter, blind as a bat, red as a beet, hot as a hare, dry as a bone, full as a flask. Atypical agents: olanzapine, quetiapine.Typical agents: chlorpromazine, fluphenazine, loxapine, perphenazine, thioridazine, trifluoperazine.Muscle relaxants: (e.g., cyclobenzaprine, orphenadrine).Tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, imipramine, nortriptyline, protriptyline, trimipramine).First-generation antihistamines (e.g., brompheniramine, carbinoxamine, chlorpheniramine, clemastine, cyproheptadine, dimenhydrinate, diphenhydramine, doxepin, doxylamine, hydroxyzine, meclizine, triprolidine).Numerous plants (e.g., various nightshade species including Atropa belladonna, Jimson weed).Īgents with mixed effects, including anticholinergic activity.
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